Isolation, Structural Elucidation, and Neuroprotective Effects of Iridoids fromValeriana jatamansi

ISOLATION AND STRUCTURAL ELUCIDATION OF THE FIRST KNOWN C-HOMOPROTOBERBERINE

A novel C-homoprotoberberine alkaloid, Hediamine (2), has been isolated from the roots of Berberis actinucantha (Berberidaceae). Conclusive proof for the structure of hediamine was obtained by its comparison with the isomeric lactam (4), by chemical transformation, and by means of spectroscopic techniques (UV, IR, MS, NMR).

Iridoids and sesquiterpenoids from the roots of Valeriana jatamansi Jones.

Three new iridoids, jatamanvaltrates R-S (1-2) and jatamanin Q (3), as well as three new sesquiterpenoids, valeriananoids D-E (4, 5) and clovane-2β-isovaleroxy-9α-ol (6), together with nine known compounds were isolated from the roots of Valeriana jatamansi Jones. Compound 2 was the first reported iridoid with fatty acid esters in the Valerianaceae family. The structures of new compounds were e...

isolation and structural elucidation of natural products in euphorbia erythradenia

Fermentation, Isolation, Structural Elucidation and Biological Activities

A fermentation broth of an unidentified fungus (N983-46) was found to produce DNAgyrase inhibitors, CJ-12,371 (1) and CJ-12,372 (2). Following isolation by solvent extraction and silica gel and ODS(reverse phase) chromatographies, the structures were determined to be novel spiro-ketal compounds with S-connguration at position C-l. CJ-12,371 and CJ-12,372 inhibit both DNA supercoiling and relaxa...

isolation and structural elucidation of the first known c-homoprotoberberine

a novel c-homoprotoberberine alkaloid, hediamine (2), has been isolated from the roots of berberis actinucantha (berberidaceae). conclusive proof for the structure of hediamine was obtained by its comparison with the isomeric lactam (4), by chemical transformation, and by means of spectroscopic techniques (uv, ir, ms, nmr).